Phenylacetic Acid → HCID 86750284, compound

HRID 1449815Notes

Reaction equation

HRID 1449815 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]([OH:18])[CH2:9][NH:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][OH:17].[C:19]1(C[C:26]([OH:28])=[O:27])[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1.[C:29]([O:32]CC)(=[O:31])[CH3:30].[CH3:35][OH:36].C(N(CC)CC)C>>[C:29]([O:32][C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][C:24]=1[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12][CH2:11][NH:10][CH2:9][CH:8]([C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[Cl:1])[OH:18])(=[O:31])[CH3:30].[C:26]([O-:28])(=[O:27])[C:35]([O-:17])=[O:36]

Participants

4

Reactant 3

HCID 999Phenylacetic AcidHCID 21980445Ethyl acetate methanol triethylamineHCID 23352640HCID 23352640, compound

Product 1

HCID 86750284HCID 86750284, compound

Procedure

Preparation according to method II from 1-(2-chlorophenyl)-2-(6-hydroxy-1-hexylamino)ethanol and phenylacetic acid. Working up by means of chromatography (ethyl acetate/methanol/triethylamine 42.5:7.5:1.0). Recrystallized as the oxalate from acetone. Melting point: 114°-117° C.

Workup

  1. customPreparation
  2. customRecrystallized as the oxalate from acetone

Sources & evidence

ORD record
ord-31c4431269864ac9a872f543631ce051
Source dataset
uspto-grants-1997_02
Patent number
US05599966

Reaction notes

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