Phenylethanolamine → HCID 86750291, compound

HRID 1449822Notes

Reaction equation

HRID 1449822 reaction equation
O1CCCC1.Br[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][C:12]([O:14][CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[O:13].[NH2:22][CH2:23][CH:24]([C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)[OH:25]>C(OCC)(=O)C.CO.C(N(CC)CC)C>[CH2:15]([O:14][C:12](=[O:13])[CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][NH:22][CH2:23][CH:24]([OH:25])[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

Participants

5

Reactant 3

HCID 1000PhenylethanolamineHCID 8028TetrahydrofuranHCID 562258Benzyl 6-bromohexanoate

Product 1

HCID 86750291HCID 86750291, compound

Reagents, catalysts & solvents 1

HCID 21980445Ethyl acetate methanol triethylamineSolvent

Procedure

According to method I (tetrahydrofuran, reflux 4 days) from benzyl 6-bromohexanoate and 2-amino-1-phenylethanol. Working up by means of chromatography (ethyl acetate/methanol/triethylamine 3:1:0.1). Melting point: 77°-78° C.

Sources & evidence

ORD record
ord-daf733f72c404b1bba8320e3cc75baf2
Source dataset
uspto-grants-1997_02
Patent number
US05599966

Reaction notes

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