HRID1449829

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6228

N,N-Dimethylformamide

C3H7NO

HCID217242

2-Amino-1-(4-amino-3,5-dichlorophenyl)ethan-1-ol

C8H10Cl2N2O

HCID23352566

未命名化合物

PRODUCTS

生成物

$结构：COc1ccc(CCCC(=O)OCCCCCCNCC(O)c2cc(Cl)c(N)c(Cl)c2)cc1.O=C([O-])/C=C\C(=O)[O-]$

HCID86750295

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID22036596

未命名化合物

PROCEDURE

实验过程

According to method I (dimethylformamide, 2 hours at 90° C.) from (6-bromo-1-hexyl)4-(4-methoxyphenyl)butanoate and 2-amino-1-(4-amino-3,5-dichlorophenyl)ethanol. Working up by means of chromatography (ethyl acetate/triethylamine 5:1). Recrystallized as the maleate from diethyl ether. Melting point: 66°-67° C.

WORKUP

后处理

customRecrystallized as the maleate from diethyl ether

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-239117809f6e47198a8b104810707a2f
来源数据集: uspto-grants-1997_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05599966
来源说明: uspto-grants-1997_02

反应 SMILES

CN(C)[CH:3]=[O:4].Br[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][O:13][C:14](=[O:26])[CH2:15][CH2:16][CH2:17][C:18]1[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[CH:20][CH:19]=1.[NH2:27][CH2:28][CH:29]([C:31]1[CH:36]=[C:35]([Cl:37])[C:34]([NH2:38])=[C:33]([Cl:39])[CH:32]=1)[OH:30]>C(OCC)(=O)C.C(N(CC)CC)C>[NH2:38][C:34]1[C:33]([Cl:39])=[CH:32][C:31]([CH:29]([OH:30])[CH2:28][NH:27][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][O:13][C:14](=[O:26])[CH2:15][CH2:16][CH2:17][C:18]2[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[CH:20][CH:19]=2)=[CH:36][C:35]=1[Cl:37].[C:3]([O-:4])(=[O:30])/[CH:16]=[CH:15]\[C:14]([O-:26])=[O:13]