Methylamine → HCID 19975707, compound

HRID 1450387Notes

Reaction equation

HRID 1450387 reaction equation
[Br:1][C:2]1[C:6]2[CH:7]=[C:8]([CH2:11]Br)[CH:9]=[CH:10][C:5]=2[O:4][C:3]=1[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[C:19]#[N:20].[CH3:21][NH2:22]>C1COCC1>[Br:1][C:2]1[C:6]2[CH:7]=[C:8]([CH2:11][NH:22][CH3:21])[CH:9]=[CH:10][C:5]=2[O:4][C:3]=1[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[C:19]#[N:20]

Participants

4

Reactant 2

HCID 6329MethylamineHCID 19975734HCID 19975734, compound

Product 1

HCID 19975707HCID 19975707, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

3.1 g (7.9 mmol) 3-Bromo-5-(bromomethyl)-2-(2-cyanophenyl)benzofuran (prepared according to EP 434 249) were dissolved in 50 ml THF, and 25 ml of a 40% aqueous solution of methylamine was added via a dropping funnel. The mixture was stirred at room temperature over night and warmed for 2 h at 40° C. The solvent was removed in vacuo, the residue stirred with water, filtrated by suction, and washed with water. The title compound was purified by column chromatography (silica gel, dichloromethane / ethanol 99:1 to 90:10) and obtained as a colorless powder after evaporation to dryness, m.p. 114° C.

Workup

  1. temperaturewarmed for 2 h at 40° C
  2. customThe solvent was removed in vacuo
  3. stirringthe residue stirred with water
  4. filtrationfiltrated by suction
  5. washwashed with water
  6. customThe title compound was purified by column chromatography (silica gel, dichloromethane / ethanol 99:1 to 90:10)
  7. customobtained as a colorless powder
  8. customafter evaporation to dryness, m.p. 114° C.

Sources & evidence

ORD record
ord-b6b60c1d30ec413b9b1bf2f6f7630bca
Source dataset
uspto-grants-1997_02
Patent number
US05602137

Reaction notes

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