Hydrochloric Acid → HCID 54025347, compound

HRID 1450626Notes

Reaction equation

HRID 1450626 reaction equation
[CH:1]([C:3]1[S:7][C:6]([C:8]2[S:9][C:10]([C:13]3[S:14][CH:15]=[CH:16][CH:17]=3)=[CH:11][CH:12]=2)=[CH:5][CH:4]=1)=O.[C:18]([OH:24])(=[O:23])[CH2:19][C:20]([OH:22])=[O:21].N1CCCCC1.Cl>O.N1C=CC=CC=1>[C:20]([C:19]([C:18]([OH:24])=[O:23])=[CH:1][C:3]1[S:7][C:6]([C:8]2[S:9][C:10]([C:13]3[S:14][CH:15]=[CH:16][CH:17]=3)=[CH:11][CH:12]=2)=[CH:5][CH:4]=1)([OH:22])=[O:21]

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 867Malonic AcidHCID 8082PiperidineHCID 454742(2,2':5',2''-Terthiophene)-5-carboxaldehyde

Product 1

HCID 54025347HCID 54025347, compoundYield 84%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 1049PyridineSolvent

Procedure

1.30 g of 5-formyl-2,2':5',2"-terthiophene, 1.04 g of malonic acid, 20 ml of pyridine and 0.1 ml of piperidine were heated at 50°-60° C. for 2 hours. 100 ml of water was added after reaction was completed. The mixture was acidified by diluted HCl and the precipitate collected was recrystallized from ethanol to give reddish crystal (1.43 g). The melting point thereof was 202°-203° C. The yield was 84%.

Workup

  1. customafter reaction
  2. customthe precipitate collected
  3. customwas recrystallized from ethanol

Sources & evidence

ORD record
ord-bfaad350160b4efb85216778114882de
Source dataset
uspto-grants-1997_02
Patent number
US05602170

Reaction notes

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