Water → HCID 19976927, compound

HRID 1450657Notes

Reaction equation

HRID 1450657 reaction equation
[NH:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1.[C:6]1([C:12]2[CH:16]=[C:15]([C:17](=[O:21])[CH:18]=[CH:19][CH3:20])[O:14][N:13]=2)[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.O>C(OCC)(=O)C>[C:6]1([C:12]2[CH:16]=[C:15]([C:17](=[O:21])[CH2:18][CH:19]([N:1]3[CH2:5][CH2:4][CH2:3][CH2:2]3)[CH3:20])[O:14][N:13]=2)[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=1

Participants

5

Reactant 3

HCID 962WaterHCID 31268PyrrolidineHCID 53643104HCID 53643104, compound

Product 1

HCID 19976927HCID 19976927, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Pyrrolidine (5 ml) was added to 1.1 g (5.2 mmol) of 3-phenyl-5-(2-butenoyl) isoxazole prepared above in the procedure (1). The resulting mixture was stirred at room temperature for 3 hours. Water and ethyl acetate were added to the reaction mixture, so that a product formed was extracted in an organic layer. The organic layer was collected, dried over anhydrous magnesium sulfate, and then concentrated, whereby 3-phenyl-5-{3-(1-pyrrolidinyl)butyryl}isoxazole was obtained as colorless oil.

Workup

  1. customprepared above in the procedure (1)
  2. customformed
  3. extractionwas extracted in an organic layer
  4. customThe organic layer was collected
  5. dry with materialdried over anhydrous magnesium sulfate
  6. concentrationconcentrated

Sources & evidence

ORD record
ord-017bc64ce5f24eebac5503f426100b8e
Source dataset
uspto-grants-1997_02
Patent number
US05602160

Reaction notes

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