Hydrochloric Acid → HCID 9886326, compound

HRID 1451048Notes

Reaction equation

HRID 1451048 reaction equation
Cl[C:2]1[C:7]([N+:8]([O-])=O)=[C:6](Cl)[N:5]=[CH:4][N:3]=1.C([NH:19][CH:20]1[CH2:25][CH2:24][CH2:23][CH2:22][CH:21]1[N:26]([CH2:29][CH3:30])[CH2:27][CH3:28])C1C=CC=CC=1.[CH2:31]([C:33]1[NH:34][CH:35]=[CH:36][N:37]=1)[CH3:32].[Sn](Cl)Cl.[C:41](N1C=CN=C1)(N1C=CN=C1)=[O:42].Cl>>[CH2:29]([N:26]([CH2:27][CH3:28])[CH:21]1[CH2:22][CH2:23][CH2:24][CH2:25][CH:20]1[NH:19][C:2]1[C:7]2[NH:8][C:41](=[O:42])[C:35]3=[CH:36][N:37]=[C:33]([CH2:31][CH3:32])[N:34]3[C:6]=2[N:5]=[CH:4][N:3]=1)[CH3:30]

Participants

7

Reactant 6

HCID 313Hydrochloric AcidHCID 203124,6-Dichloro-5-nitropyrimidineHCID 24479Stannous ChlorideHCID 661302-EthylimidazoleHCID 682631,1'-CarbonyldiimidazoleHCID 19358841HCID 19358841, compound

Product 1

HCID 9886326HCID 9886326, compound

Procedure

Prepared by treatment of 4,6-dichloro-5-nitropyrimidine with N-benzyl-2-(diethylamino)cyclohexylamine, followed by reaction with 2-ethylimidazole, reduction with tin (II) chloride, cyclization with carbonyldiimidazole and debenzylation with refluxing 5N HCl for 3 h.

Sources & evidence

ORD record
ord-a16114a318324d689127390af3ae99de
Source dataset
uspto-grants-1997_02
Patent number
US05602252

Reaction notes

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