Methyl iodide → HCID 21475738, compound

HRID 1451198Notes

Reaction equation

HRID 1451198 reaction equation
[CH2:1]([N:3]([CH3:7])[C:4]([NH2:6])=[S:5])[CH3:2].C[I:9].[C:10](OCC)(=O)C>CN(C)C=O>[IH:9].[CH2:1]([N:3]([CH3:7])[C:4](=[NH:6])[S:5][CH3:10])[CH3:2]

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 8857Ethyl AcetateHCID 13848133HCID 13848133, compound

Product 1

HCID 21475738HCID 21475738, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

5.8 g (49 mmol) of N-ethyl-N-methylthiourea was dissolved in 10 ml of N,N-dimethylformamide. 8.8 g (62 mmol) of methyl iodide was added at room temperature, and the mixture was stirred at room temperature for 15 hours. 500 ml of ethyl acetate was added to the mixture, and precipitated crystals were collected by filtration and then washed with ethyl acetate to obtain 3.1 g of N-ethyl-N-methyl-S-methylisothiourea hydroiodide as pale yellow crystals. Melting point: 94°-97° C.

Workup

  1. customprecipitated crystals
  2. filtrationwere collected by filtration
  3. washwashed with ethyl acetate

Sources & evidence

ORD record
ord-57656b07a0eb4f01a8a1cbe835fbdfba
Source dataset
uspto-grants-1997_02
Patent number
US05604179

Reaction notes

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