Methyl iodide → HCID 21475759, compound

HRID 1451199Notes

Reaction equation

HRID 1451199 reaction equation
[CH3:1][O:2][N:3]([CH3:7])[C:4]([NH2:6])=[S:5].C[I:9].[C:10](OCC)(=O)C>CN(C)C=O>[IH:9].[CH3:1][O:2][N:3]([CH3:7])[C:4](=[NH:6])[S:5][CH3:10]

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 8857Ethyl AcetateHCID 21475728HCID 21475728, compound

Product 1

HCID 21475759HCID 21475759, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

1.76 g (14.7 mmol) of N-methoxy-N-methylthiourea was dissolved in 5 ml of N,N-dimethylformamide. 2.09 g (14.7 mmol) of methyl iodide was added thereto at room temperature, and the mixture was stirred at room temperature for 15 hours. 500 ml of ethyl acetate was added thereto, and precipitated crystals were collected by filtration and then washed with ethyl acetate to obtain 2.7 g of N-methoxy-N-methyl-S-methylisothiourea hydroiodide as pale yellow crystals. Melting point: 122°-124° C.

Workup

  1. customprecipitated crystals
  2. filtrationwere collected by filtration
  3. washwashed with ethyl acetate

Sources & evidence

ORD record
ord-0050d44fe5114a2b87972c01badef3b7
Source dataset
uspto-grants-1997_02
Patent number
US05604179

Reaction notes

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