反应详情

To a mixture of pyrazole (88.3 g, 1.297 mol) and formalin (116 ml, 33%, 1.4 mol) in 450 ml of ethanol at 0° C. was added pyrrolidine (101.2 g, 1.425 mol) dropwise, and the mixture was heated to reflux under nitrogen for 5 h. The reaction mixture was cooled, and concentrated in vacuo. The residue was distilled (57°-58° C./0.05 mm) to afford 140 g (55.12%) of 1-(1-pyrrolidinomethyl)-pyrazole.

1. temperaturethe mixture was heated
2. temperatureto reflux under nitrogen for 5 h
3. temperatureThe reaction mixture was cooled
4. concentrationconcentrated in vacuo
5. distillationThe residue was distilled (57°-58° C./0.05 mm)