Methane → N-[2-(4-Carboxymethoxyphenyl)-1-methylethyl]-2-(2-amino-thiazol-4-yl)morpholine dichloride

HRID 1451459Notes

Reaction equation

HRID 1451459 reaction equation
[C:1]([CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([CH2:13][CH:14]([N:16]2[CH2:21][CH2:20][O:19][CH:18]([C:22]3[N:23]=[C:24]([NH:27]C(C)=O)[S:25][CH:26]=3)[CH2:17]2)[CH3:15])=[CH:9][CH:8]=1)([O:3]C)=[O:2].[ClH:31].C>>[Cl-:31].[Cl-:31].[C:1]([CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([CH2:13][CH:14]([N:16]2[CH2:21][CH2:20][O:19][CH:18]([C:22]3[N:23]=[C:24]([NH2:27])[S:25][CH:26]=3)[CH2:17]2)[CH3:15])=[CH:9][CH:8]=1)([OH:3])=[O:2]

Participants

4

Reactant 3

HCID 297MethaneHCID 313Hydrochloric AcidHCID 19974192N-[2-(4-carbomethoxymethoxyphenyl)1-methylethyl]-2-(2-acetamino-thiazol-4-yl)morpholine

Product 1

HCID 19974372N-[2-(4-Carboxymethoxyphenyl)-1-methylethyl]-2-(2-amino-thiazol-4-yl)morpholine dichloride

Procedure

1.6 g (0.0037 mol) of N-[2-(4-carbomethoxymethoxyphenyl)-1-methylethyl]-2-(2-acetamino-thiazol-4-yl)-morpholine in 100 ml of 18% strength hydrochloric acid are heated to reflux under nitrogen for 48 hours. 1.5 g of active charcoal are added to the reaction solution which is throughly stirred and filtered. The solution is then concentrated, and the product is dried in vacuo over potassium hydroxide.

Workup

  1. temperatureto reflux under nitrogen for 48 hours
  2. filtrationfiltered
  3. concentrationThe solution is then concentrated
  4. dry with materialthe product is dried in vacuo over potassium hydroxide

Sources & evidence

ORD record
ord-b8f2cda5d562436499d4eb7596a7cb78
Source dataset
uspto-grants-1997_02
Patent number
US05604225

Reaction notes

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