Diazomethane → HCID 22148996, compound

HRID 1451536Notes

Reaction equation

HRID 1451536 reaction equation
[Br:1][C:2]1[CH:25]=[CH:24][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12]([O:16][CH3:17])=[CH:13][CH:14]=3)[C:9]([CH2:18][CH2:19][C:20]([OH:22])=[O:21])=[C:8]2[CH3:23])=[CH:4][CH:3]=1.[N+](=[CH2:28])=[N-]>CCOC(C)=O>[Br:1][C:2]1[CH:25]=[CH:24][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12]([O:16][CH3:17])=[CH:13][CH:14]=3)[C:9]([CH2:18][CH2:19][C:20]([O:22][CH3:28])=[O:21])=[C:8]2[CH3:23])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 9550DiazomethaneHCID 22148991HCID 22148991, compound

Product 1

HCID 22148996HCID 22148996, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To a solution of the compound from Example 1 (75 mg, 0.19 mmol) in 10 mL EtOAc was added ethereal diazomethane solution until a yellow colour persisted. The solution was concentrated in vacuo and crystalized from ether/hexanes to provide 67 mg of the title compound.

Workup

  1. concentrationThe solution was concentrated in vacuo
  2. customcrystalized from ether/hexanes

Sources & evidence

ORD record
ord-23bdc2ce63ed4907bd9cbc0368be09df
Source dataset
uspto-grants-1997_02
Patent number
US05604253

Reaction notes

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