反应详情

A mixture of 1-(2-bromoethyl)-3-nitrobenzene (2.3 g), 1,2,3,4-tetrahydro-6,7-dimethoxyisoquinoline hydrochloride (2.3 g) and potassium carbonate (3 g) in DMF (50 ml) was heated at 50° for 12 h. The mixture was then filtered and the filtrate evaporated. The residue was then taken up in water, extracted with dichloromethane, dried, evaporated and purified by column chromatography eluting with dichloromethane/methanol (99:1) to give the title compound (1.4 g) as a yellow oil. NMR includes signals at d 3.6 (2H,s,N--CH2Ar), 3.75 (6H,s,OCH3).

1. temperaturewas heated at 50° for 12 h
2. filtrationThe mixture was then filtered
3. customthe filtrate evaporated
4. extractionextracted with dichloromethane
5. customdried
6. customevaporated
7. custompurified by column chromatography
8. washeluting with dichloromethane/methanol (99:1)