HCID 15200703, compound → HCID 19972869, compound

HRID 1451701Notes

Reaction equation

HRID 1451701 reaction equation
[CH3:1][N:2]([CH3:27])[C:3]1[CH:8]=[CH:7][C:6]([CH:9]2[CH:22]=[CH:21][NH:20][C:19]3[C:18](=[O:23])[C:17]4[NH:16][C:15](=[O:24])[CH:14]=[C:13]([CH3:25])[C:12]=4[C:11](=[O:26])[C:10]2=3)=[CH:5][CH:4]=1>C1(C)C(C)=CC=CC=1>[CH3:27][N:2]([CH3:1])[C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:22]=[CH:21][N:20]=[C:19]3[C:10]=2[C:11](=[O:26])[C:12]2[C:13]([CH3:25])=[CH:14][C:15](=[O:24])[NH:16][C:17]=2[C:18]3=[O:23])=[CH:5][CH:4]=1

Participants

3

Reactant 1

HCID 15200703HCID 15200703, compound

Product 1

HCID 19972869HCID 19972869, compoundYield 80%

Reagents, catalysts & solvents 1

HCID 7237O-XyleneSolvent

Procedure

A solution of 25 mg (0.07 mmol) of 3 in xylene (60 ml) was refluxed for 16 hours while air was bubbling through the solution. After evaporation of the solvent, the residue was purified by silica gel chromatography, using ethyl acetate as eluent to yield 20 mg (80%) of 6.

Workup

  1. customwas bubbling through the solution
  2. customAfter evaporation of the solvent
  3. customthe residue was purified by silica gel chromatography

Sources & evidence

ORD record
ord-91b37fa60f194ae0b03532e900609a18
Source dataset
uspto-grants-1997_02
Patent number
US05605905

Reaction notes

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