Water → HCID 19973473, compound

HRID 1452032Notes

Reaction equation

HRID 1452032 reaction equation
[C:1]1(=[O:10])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][CH2:2]1.[N:11]1[CH:16]=[CH:15][C:14]([CH:17]=O)=[CH:13][CH:12]=1.C1(C)C=CC(S(O)(=O)=O)=CC=1.O>C1(C)C=CC=CC=1>[N:11]1[CH:12]=[CH:13][C:14]([CH:17]2[C:3](=[CH2:2])[C:4]3[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=3)[C:1]2=[O:10])=[CH:15][CH:16]=1

Participants

6

Reactant 4

HCID 962WaterHCID 6101p-Toluenesulfonic acidHCID 67351-IndanoneHCID 133894-Pyridinecarboxaldehyde

Product 1

HCID 19973473HCID 19973473, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

##STR5## 13.2 g of indanone, 15 g of pyridine-4-aldehyde and 19 g of p-toluenesulphonic acid were heated to boiling under reflux in a water separator for 5 h in 250 ml of toluene. The resulting precipitate was filtered off with suction after cooling and stirred at room temperature for 30 rain in 10% sodium carbonate solution. The resulting, pale-yellow precipitate was filtered off with suction, washed with water and dried in air. Yield: 19.3 g (87%)

Workup

  1. filtrationThe resulting precipitate was filtered off with suction
  2. temperatureafter cooling
  3. filtrationThe resulting, pale-yellow precipitate was filtered off with suction
  4. washwashed with water
  5. customdried in air

Sources & evidence

ORD record
ord-2e022ab4fc3648d384230cf0d29e3677
Source dataset
uspto-grants-1997_02
Patent number
US05606064

Reaction notes

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