Acetonitrile → HCID 86750390, compound

HRID 1452034Notes

Reaction equation

HRID 1452034 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([CH:7]2[C:15](=C)[C:14]3[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=3)[C:8]2=[O:17])=[CH:3][CH:2]=1.[CH2:18]([Br:25])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1.[C:26](#N)C>>[Br-:25].[CH2:18]([N+:1]1[CH:6]=[CH:5][C:4](=[C:7]2[CH2:15][C:14]3[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=3)[C:8]2=[O:17])[CH2:3][C:2]=1[CH3:26])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

Participants

4

Reactant 3

HCID 6342AcetonitrileHCID 7498Benzyl BromideHCID 19973473HCID 19973473, compound

Product 1

HCID 86750390HCID 86750390, compound

Procedure

##STR7## 10 g of compound from Example 1 were dissolved in 150 ml of boiling acetonitrile and 7.5 g of benzyl bromide were added hot. The mixture was heated to boiling under reflux for a further 2 h, the product precipitating. It was allowed to cool, and the resulting precipitate was filtered off with suction, washed with acetonitrile and methyl tert-butyl ether in the sequence indicated and dried in air.

Workup

  1. temperatureThe mixture was heated
  2. temperatureunder reflux for a further 2 h
  3. customthe product precipitating
  4. temperatureto cool
  5. filtrationthe resulting precipitate was filtered off with suction
  6. washwashed with acetonitrile and methyl tert-butyl ether in the sequence
  7. customdried in air

Sources & evidence

ORD record
ord-e0253da9fe84418f975b0382938190b4
Source dataset
uspto-grants-1997_02
Patent number
US05606064

Reaction notes

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