反应详情

To a mixed solution of THF (24 mL) and water (6 mL) containing 6-allyl-5,7-dichloropyrazolo[1,5-a]pyrimidine (1.82 g, 7.89 mmol), sodium periodate (5.12 g, 23.9 mmol) and osmium tetraoxide (2.5w/v % in tert-butanol, 3 mL, 0.23 mmol) were added with ice-cooling. After this mixture was stirred at room temperature for 3 hr, aqueous sodium sulfite was added here. The resultant mixture was extracted with ethyl acetate and the organic layer was washed with aqueous sodium hydrogen carbonate and then brine and dried over sodium sulfate. After the sodium sulfate was filtered off, the solvent was distilled off to obtain 5,7-dichloro-6-(2-oxoethyl)pyrazolo[1,5-a]pyrimidine.

1. additionwere added with ice-
2. temperaturecooling
3. extractionThe resultant mixture was extracted with ethyl acetate
4. washthe organic layer was washed with aqueous sodium hydrogen carbonate
5. dry with materialbrine and dried over sodium sulfate
6. filtrationAfter the sodium sulfate was filtered off
7. distillationthe solvent was distilled off