反应详情

温度

85 °C

To an isopropanol (3.0 mL) solution containing 6-[2-(tert-butyldimethylsilanyloxy)ethyl]-5,7-dichloropyrazolo[1,5-a]pyrimidine (512 mg, 1.49 mmol), triethylamine (836 μL, 5.96 mmol) and 4-(2-methoxyethoxy)phenylamine (299 mg, 1.79 mmol) were added, and this mixture was heated at 85° C. with stirring. After the reaction, the solvent was concentrated, sodium hydrogen carbonate was added here, and the mixture was extracted with ethyl acetate. The combined ethyl acetate layer was dried over sodium sulfate. After the sodium sulfate was filtered off, the solvent was distilled off to obtain the title compound.

1. additionwere added
2. customAfter the reaction
3. concentrationthe solvent was concentrated
4. additionsodium hydrogen carbonate was added here
5. extractionthe mixture was extracted with ethyl acetate
6. dry with materialThe combined ethyl acetate layer was dried over sodium sulfate
7. filtrationAfter the sodium sulfate was filtered off
8. distillationthe solvent was distilled off