反应详情

温度

40 °C

To an isopropanol (3 mL) solution containing 3-(5,7-dichloropyrazolo[1,5-a]pyrimidin-6-yl)propan-1-ol (224 mg, 0.910 mmol), triethylamine (253 μL, 1.82 mmol) and phenethidine (128 μL, 1.00 mmol) were added, and this mixture was stirred at 40° C. for 5 hr. After the reaction, the solvent was distilled off, aqueous sodium hydrogen carbonate was added to the residue, and the mixture was extracted with ethyl acetate. The combined ethyl acetate layer was dried over sodium sulfate. After the sodium sulfate was filtered off, the filtrate was concentrated and the residue was purified with column chromatography (30% ethyl acetate-hexane) to obtain the title compound (212 mg).

1. additionwere added
2. customAfter the reaction
3. distillationthe solvent was distilled off
4. additionaqueous sodium hydrogen carbonate was added to the residue
5. extractionthe mixture was extracted with ethyl acetate
6. dry with materialThe combined ethyl acetate layer was dried over sodium sulfate
7. filtrationAfter the sodium sulfate was filtered off
8. concentrationthe filtrate was concentrated
9. customthe residue was purified with column chromatography (30% ethyl acetate-hexane)