反应详情

温度

50 °C

100 mg (0.2 mmol) of 2-chloro-4-[2,2,2-trifluoro-1-(4-methoxy-benzyloxy)-1-trifluoromethyl-ethyl]-phenol (example 3) in 4 ml of acetone were treated with 47 mg (0.3 mmol) of benzyl bromide, 157 mg (0.5 mmol) of Cs2CO3 and 4 mg (0.025 mmol) of potassium iodide. The reaction mixture was stirred at 50° C. overnight, cooled to room temperature, filtered and the solvent was evaporated. The residue was dissolved in EtOAc and water, the phases were separated and the inorganic one was extracted with EtOAc. The combined organic phases were washed with brine, dried (Na2SO4) and evaporated to give 82 mg (67%) of crude 1-benzyloxy-2-chloro-4-[2,2,2-trifluoro-1-(4-methoxy-benzyloxy)-1-trifluoromethyl-ethyl]-benzene.

1. temperaturecooled to room temperature
2. filtrationfiltered
3. customthe solvent was evaporated
4. dissolutionThe residue was dissolved in EtOAc
5. customwater, the phases were separated
6. extractionthe inorganic one was extracted with EtOAc
7. washThe combined organic phases were washed with brine
8. dry with materialdried (Na2SO4)
9. customevaporated