Trifluoroacetic acid → HCID 68866292, compound

HRID 1453044Notes

Reaction equation

HRID 1453044 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:10]2[S:11][CH:12]=[CH:13][N:14]=2)O)=[CH:4][C:3]=1[F:15].C(O)(C(F)(F)F)=O.C([SiH](CC)CC)C>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:10]2[S:11][CH:12]=[CH:13][N:14]=2)=[CH:4][C:3]=1[F:15]

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 12052TriethylsilaneHCID 68868665HCID 68868665, compound

Product 1

HCID 68866292HCID 68866292, compound

Procedure

A solution of (4-Bromo-3-fluoro-phenyl)-thiazol-2-yl-methanol (3.4 g, 12.6 mmol), TFA (25 mL), and Triethylsilane (10 mL, 63 mmol), were refluxed overnight. The reaction was then concentrated under vacuum, and purified by silica gel chromatography (gradient elution 10-40% Ethylacetate/Hexanes). Yield 1.96 g, 61%.

Workup

  1. concentrationThe reaction was then concentrated under vacuum
  2. custompurified by silica gel chromatography (gradient elution 10-40% Ethylacetate/Hexanes)

Sources & evidence

ORD record
ord-620393d39a114a16b9b44aa4dadb04f3
Source dataset
uspto-grants-2009_01
Patent number
US07473790B2

Reaction notes

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