Indoline → HCID 178478370, compound

HRID 1453549Notes

Reaction equation

HRID 1453549 reaction equation
[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([NH:6][CH:7]=[N:8]2)=[C:4](Cl)[N:3]=1.[NH:12]1[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[CH2:14][CH2:13]1>C(O)CCC>[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][NH:8]2)=[C:4]([N:12]2[C:20]3[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=3)[CH2:14][CH2:13]2)[N:3]=1

Participants

4

Reactant 2

HCID 10328IndolineHCID 53244122,6-Dichloropurine

Product 1

HCID 178478370HCID 178478370, compoundYield 96.4%

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

189 mg of 2,6-dichloropurine, 4 ml of butanol and 143 mg (1.2 equivalents) of indoline are mixed and brought to a temperature of 80° C. for approximately 17 hours. The mixture is allowed to return to ambient temperature. Partial drying, washing with ethyl ether and drying under vacuum are carried out, and 262 mg of expected product are obtained in the form of beige-colored crystals.

Workup

  1. customto return to ambient temperature
  2. customPartial drying
  3. washwashing with ethyl ether
  4. customdrying under vacuum

Sources & evidence

ORD record
ord-a44a95748b394c6c925860e1c8b6d536
Source dataset
uspto-grants-2009_01
Patent number
US07476670B2

Reaction notes

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