Diisopropylethylamine → HCID 178454026, compound

HRID 1453610Notes

Reaction equation

HRID 1453610 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([C:11]1[N:19]=[C:18]([NH:20][C@H:21]3[CH2:26][CH2:25][C@H:24]([NH:27][C:28]([O:30][C:31]([CH3:34])([CH3:33])[CH3:32])=[O:29])[CH2:23][CH2:22]3)[N:17]=[C:16]3[C:12]=1[N:13]=[CH:14][N:15]3[C:35]([O:37][C:38]([CH3:41])([CH3:40])[CH3:39])=[O:36])[CH2:6][CH2:5]2.[S:42]1[CH:46]=[CH:45][CH:44]=[C:43]1[CH2:47][C:48](Cl)=[O:49].C(N(C(C)C)CC)(C)C>ClCCl>[S:42]1[CH:46]=[CH:45][CH:44]=[C:43]1[CH2:47][C:48]([NH:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([C:11]1[N:19]=[C:18]([NH:20][C@H:21]3[CH2:26][CH2:25][C@H:24]([NH:27][C:28]([O:30][C:31]([CH3:33])([CH3:34])[CH3:32])=[O:29])[CH2:23][CH2:22]3)[N:17]=[C:16]3[C:12]=1[N:13]=[CH:14][N:15]3[C:35]([O:37][C:38]([CH3:41])([CH3:40])[CH3:39])=[O:36])[CH2:6][CH2:5]2)=[O:49]

Participants

5

Reactant 3

HCID 81531DiisopropylethylamineHCID 1623622-Thiopheneacetyl chlorideHCID 178454025HCID 178454025, compound

Product 1

HCID 178454026HCID 178454026, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

40 mg of product obtained in stage 4 are mixed with 11.4 mg of 2-thiopheneacetyl chloride, 25 μl of diisopropylethylamine and 2 ml of dichloromethane. The mixture is stirred for 1 hour at ambient temperature, and then washing with brine, drying over magnesium sulfate and evaporation to dryness are carried out.

Workup

  1. washwashing with brine
  2. dry with materialdrying over magnesium sulfate and evaporation to dryness

Sources & evidence

ORD record
ord-9f4bbec9b5274006bc6dace5f08619b4
Source dataset
uspto-grants-2009_01
Patent number
US07476670B2

Reaction notes

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