Triethylamine → HCID 64888821, compound

HRID 1453667Notes

Reaction equation

HRID 1453667 reaction equation
[NH2:1][C:2]1([C:7]([OH:9])=[O:8])[CH2:6][CH2:5][O:4][CH2:3]1.[Br:10][C:11]1[S:15][C:14]([C:16](O)=[O:17])=[CH:13][CH:12]=1.S(Cl)(Cl)=O.C(N(CC)CC)C>ClCCl>[Br:10][C:11]1[S:15][C:14]([C:16]([NH:1][C:2]2([C:7]([OH:9])=[O:8])[CH2:6][CH2:5][O:4][CH2:3]2)=[O:17])=[CH:13][CH:12]=1

Participants

6

Reactant 4

HCID 8471TriethylamineHCID 24386Thionyl ChlorideHCID 3491155-Bromothiophene-2-carboxylic acidHCID 5436623-Aminotetrahydrofuran-3-carboxylic acid

Product 1

HCID 64888821HCID 64888821, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Prepared analogously to Example 53a from 3-amino-tetrahydrofuran-3-carboxylic acid and 5-bromo-thiophene-2-carboxylic acid with thionyl chloride and N,O-bis-(trimethylsilyl)-trifluoroacetamid in dichloromethane with triethylamine.

Sources & evidence

ORD record
ord-5aad11ab4c9d459f8e4df41dce459861
Source dataset
uspto-grants-2009_01
Patent number
US07476663B2

Reaction notes

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