Hydrochloric Acid → HCID 67316971, compound

HRID 1453684Notes

Reaction equation

HRID 1453684 reaction equation
C([O:5][C:6](=[O:28])[CH2:7][N:8]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[C:10]([C:17]2[C:26]3[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=3)[C:20](Cl)=[N:19][N:18]=2)=[CH:9]1)(C)(C)C.[OH-:29].[Na+].Cl>C1COCC1>[O:29]=[C:20]1[C:21]2[C:26](=[CH:25][CH:24]=[CH:23][CH:22]=2)[C:17]([C:10]2[C:11]3[C:16](=[CH:15][CH:14]=[CH:13][CH:12]=3)[N:8]([CH2:7][C:6]([OH:5])=[O:28])[CH:9]=2)=[N:18][NH:19]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 86604943HCID 86604943, compound

Product 1

HCID 67316971HCID 67316971, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
60 °C

Procedure

The product of step b) (50 mg, 0.13 mmol) was dissolved in 4 mL THF. NaOH (0.52 mL of 1 M aq) was added and the reaction was heated to 60° C. for 3 days. The reaction was cooled, acidified with 1 M HCl, and extracted into DCM. Concentration gave the sub-title product as a yellow oil. MS: ESI (negative): 318 (M−H).

Workup

  1. temperatureThe reaction was cooled
  2. extractionextracted into DCM
  3. concentrationConcentration

Sources & evidence

ORD record
ord-9134cff22f134bcba3c5a31c2048f10d
Source dataset
uspto-grants-2009_01
Patent number
US07476667B2

Reaction notes

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