反应详情

温度

70 °C

The product of step a) (200 mg, 0.71 mmol) was treated with Et3N (0.71 mmol, 98 uL), n-butyl hydrazine oxalate (0.71 mmol, 126 mg) and 10 mL toluene. The suspension was refluxed for 48 h. The reaction was cooled, treated with 15 mL EtOAc and 5 mL 1M NaOH, and heated to 70° C. for 30 min. The organic layer was filtered through silica gel and further eluted with EtOAc. The combined eluent was concentrated to dryness to give the sub-titled compound which was used without further purification.

1. temperatureThe suspension was refluxed for 48 h
2. temperatureThe reaction was cooled
3. filtrationThe organic layer was filtered through silica gel
4. washfurther eluted with EtOAc
5. concentrationThe combined eluent was concentrated to dryness