Triethylamine → HCID 86605570, compound

HRID 1453955Notes

Reaction equation

HRID 1453955 reaction equation
[CH3:1][S:2](Cl)(=[O:4])=[O:3].[OH:6][CH2:7][CH2:8][C:9]1[C:10]([N+:15]([O-:17])=[O:16])=[N:11][CH:12]=[CH:13][CH:14]=1.C(N(CC)CC)C.C(=O)(O)[O-].[Na+]>C(Cl)Cl>[CH3:1][S:2]([O:6][CH2:7][CH2:8][C:9]1[C:10]([N+:15]([O-:17])=[O:16])=[N:11][CH:12]=[CH:13][CH:14]=1)(=[O:4])=[O:3]

Participants

6

Reactant 4

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 516892Sodium BicarbonateHCID 68535847HCID 68535847, compound

Product 1

HCID 86605570HCID 86605570, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

Methane sulfonyl chloride (0.16 mL, 2.14 mmol) was added to a solution of 3-(2-hydroxyethyl)-2-nitropyridine (0.300 g, 1.78 mmol) and triethylamine (0.37 mL, 2.67 mmol) in methylene chloride (5 mL) at 0° C. under argon. After 1 h the reaction was worked up with saturated sodium bicarbonate and methylene chloride, and the organic phase dried over sodium sulfate and concentrated to give the title compound MS 247 (M+1).

Workup

  1. dry with materialthe organic phase dried over sodium sulfate
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-482a65953a72428a98171225de543763
Source dataset
uspto-grants-2009_01
Patent number
US07476665B2

Reaction notes

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