Lithium Hydroxide → HCID 67301680, compound

HRID 1454391Notes

Reaction equation

HRID 1454391 reaction equation
[Li+].[OH-].[O:3]=[C:4]1[N:10]([CH:11]2[CH2:16][CH2:15][N:14]([C:17]([O:19][C@@H:20]([C:30]([O:32]C)=[O:31])[CH2:21][C:22]3[CH:23]=[N:24][C:25]([NH2:29])=[C:26]([CH3:28])[CH:27]=3)=[O:18])[CH2:13][CH2:12]2)[CH2:9][CH2:8][C:7]2[CH:34]=[CH:35][CH:36]=[CH:37][C:6]=2[NH:5]1>O.C1COCC1>[O:3]=[C:4]1[N:10]([CH:11]2[CH2:12][CH2:13][N:14]([C:17]([O:19][C@@H:20]([C:30]([OH:32])=[O:31])[CH2:21][C:22]3[CH:23]=[N:24][C:25]([NH2:29])=[C:26]([CH3:28])[CH:27]=3)=[O:18])[CH2:15][CH2:16]2)[CH2:9][CH2:8][C:7]2[CH:34]=[CH:35][CH:36]=[CH:37][C:6]=2[NH:5]1

Participants

5

Reactant 2

HCID 3939Lithium HydroxideHCID 67301411HCID 67301411, compound

Product 1

HCID 67301680HCID 67301680, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

A solution of 100 mg (4.18 mmol) LiOH in 25 mL water was added to a solution of 1.27 g (2.64 mmol) of (R)-2-(6-amino-5-methyl-pyridin-3-yl)-1-methoxycarbonyl-ethyl 4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidine-1-carboxylate in 30 mL THF and the reaction solution was stirred for 1 h at RT. The mixture was evaporated down i.vac., the residue was taken up in water, 2 M KHSO4 solution were added with stirring, the supernatant solution was decanted off, the residue was dried, stirred with THF and the product was filtered.

Workup

  1. customThe mixture was evaporated down i.vac
  2. addition2 M KHSO4 solution were added
  3. stirringwith stirring
  4. customthe supernatant solution was decanted off
  5. customthe residue was dried
  6. stirringstirred with THF
  7. filtrationthe product was filtered

Sources & evidence

ORD record
ord-3792eb04cebc417ba1885ed2c2ea8753
Source dataset
uspto-grants-2009_01
Patent number
US07479488B2

Reaction notes

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