Dimethylformamide → Ethyl 5-iodothiazole-4-carboxylate

HRID 145458Notes

Reaction equation

HRID 145458 reaction equation
[C:13]([O:14][N:15]=[O:16])([CH3:17])([CH3:18])[CH3:19].[NH2:1][c:2]1[s:3][c:4]([I:12])[c:5]([C:7](=[O:8])[O:9][CH2:10][CH3:11])[n:6]1.[O:20]=[CH:21][N:22]([CH3:23])[CH3:24]>>[cH:2]1[s:3][c:4]([I:12])[c:5]([C:7](=[O:8])[O:9][CH2:10][CH3:11])[n:6]1

Participants

4

Reactant 3

HCID 6228DimethylformamideHCID 10906Tert-Butyl nitriteHCID 45117588Ethyl 2-amino-5-iodo-1,3-thiazole-4-carboxylate

Product 1

HCID 59705069Ethyl 5-iodothiazole-4-carboxylate

Sources & evidence

ORD record
ord-4aba942160694770b7d1c925a98959cb
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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