Dimethylformamide → 6-(3-ethoxyphenyl)-N-[[2-(trifluoromethyl)-1H-indol-5-yl]methyl]pyridine-3-carboxamide

HRID 145465Notes

Reaction equation

HRID 145465 reaction equation
[CH2:25]([CH3:26])[O:27][c:28]1[cH:29][c:30](-[c:34]2[cH:35][cH:36][c:37]([C:40](=[O:41])[OH:42])[cH:38][n:39]2)[cH:31][cH:32][cH:33]1.[CH:43]([N:44]([CH2:45][CH3:46])[CH:47]([CH3:48])[CH3:49])([CH3:50])[CH3:51].[F:52][C:53]([c:54]1[nH:55][c:56]2[cH:57][cH:58][c:59]([CH2:63][NH2:64])[cH:60][c:61]2[cH:62]1)([F:65])[F:66].[O:67]=[CH:68][N:69]([CH3:70])[CH3:71].[P-:1]([F:2])([F:3])([F:4])([F:5])([F:6])[F:7].[n:8]1([O:9][C:10]([N:11]([CH3:12])[CH3:13])=[N+:14]([CH3:15])[CH3:16])[c:17]2[n:18][cH:19][cH:20][cH:21][c:22]2[n:23][n:24]1>>[CH2:25]([CH3:26])[O:27][c:28]1[cH:29][c:30](-[c:34]2[cH:35][cH:36][c:37]([C:40](=[O:42])[NH:64][CH2:63][c:59]3[cH:58][cH:57][c:56]4[nH:55][c:54]([C:53]([F:52])([F:65])[F:66])[cH:62][c:61]4[cH:60]3)[cH:38][n:39]2)[cH:31][cH:32][cH:33]1

Participants

7

Reactant 6

HCID 6228DimethylformamideHCID 9886HexafluorophosphateHCID 81531DiisopropylethylamineHCID 4641409(Dimethylamino)-N,N-dimethyl(3H-(1,2,3)triazolo(4,5-b)pyridin-3-yloxy)methaniminiumHCID 532232596-(3-Ethoxyphenyl)nicotinic acidHCID 58126817(2-(Trifluoromethyl)-1h-indol-5-yl)methanamine

Product 1

HCID 444662006-(3-ethoxyphenyl)-N-[[2-(trifluoromethyl)-1H-indol-5-yl]methyl]pyridine-3-carboxamide

Sources & evidence

ORD record
ord-e62c228f2b80468f95d7b27bf13d4264
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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