Diethyl Ether → ethyl N-trimethylsilylpiperidin-4-ylcarboxylate

HRID 145476Notes

Reaction equation

HRID 145476 reaction equation
[CH3:12][CH2:13][N:14]([CH2:15][CH3:16])[CH2:17][CH3:18].[CH3:19][Si:20]([CH3:21])([CH3:22])[Cl:23].[CH3:24][CH2:25][O:26][CH2:27][CH3:28].[NH:1]1[CH2:2][CH2:3][CH:4]([C:7](=[O:8])[O:9][CH2:10][CH3:11])[CH2:5][CH2:6]1>>[N:1]1([Si:20]([CH3:19])([CH3:21])[CH3:22])[CH2:2][CH2:3][CH:4]([C:7](=[O:8])[O:9][CH2:10][CH3:11])[CH2:5][CH2:6]1

Participants

5

Reactant 4

HCID 3283Diethyl EtherHCID 6397ChlorotrimethylsilaneHCID 8471TriethylamineHCID 70770Ethyl 4-piperidinecarboxylate

Product 1

HCID 22006945ethyl N-trimethylsilylpiperidin-4-ylcarboxylate

Sources & evidence

ORD record
ord-64acd9a3cd054d518bbc501260201b1a
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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