Hydroxylamine → 51519-20-1

HRID 1454801Notes

Reaction equation

HRID 1454801 reaction equation
C[N:2](C)[CH:3]=[N:4][C:5]1[CH:10]=[N:9][CH:8]=[CH:7][N:6]=1.N[OH:13]>O1CCCC1>[OH:13][NH:2][CH:3]=[N:4][C:5]1[CH:10]=[N:9][CH:8]=[CH:7][N:6]=1

Participants

4

Reactant 2

HCID 787HydroxylamineHCID 1222947551519-09-6

Product 1

HCID 13560477151519-20-1

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
80 °C

Procedure

A solution of N,N-dimethyl-N′-pyrazin-2-ylimidoformamide (189 g) from Step A in tetrahydrofuran (400 mL) was treated drop wise with 50% aqueous solution of hydroxylamine (245.7 mL) at 0° C., then warmed up to 80° C. for 2.5 h. Tetrahydrofuran was removed by rotoevaporation and the resulting aqueous mixture kept cold in a refrigerator. The resulting solid was filtered and rinsed with cold diethyl ether to yield the desired product.

Workup

  1. customTetrahydrofuran was removed by rotoevaporation
  2. filtrationThe resulting solid was filtered
  3. washrinsed with cold diethyl ether

Sources & evidence

ORD record
ord-354e37c2d3d34199aa47b4bed8435fd3
Source dataset
uspto-grants-2009_01
Patent number
US07482336B2

Reaction notes

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