2-Butene, 1-bromo-3-methyl- → 3-Methyl-7-(3-methyl-2-buten-1-yl)-8-bromo-xanthine

HRID 1454943Notes

Reaction equation

HRID 1454943 reaction equation
CCN(C(C)C)C(C)C.[CH3:10][C:11]([CH3:15])=[CH:12][CH2:13]Br.[CH3:16][N:17]1[C:25]2[N:24]=[C:23]([Br:26])[NH:22][C:21]=2[C:20](=[O:27])[NH:19][C:18]1=[O:28]>CN(C)C=O.O>[CH3:16][N:17]1[C:25]2[N:24]=[C:23]([Br:26])[N:22]([CH2:13][CH:12]=[C:11]([CH3:15])[CH3:10])[C:21]=2[C:20](=[O:27])[NH:19][C:18]1=[O:28]

Participants

6

Reactant 3

HCID 700922-Butene, 1-bromo-3-methyl-HCID 81531DiisopropylethylamineHCID 15487978-bromo-3-methyl-3,7-dihydro-1H-purine-2,6-dione

Product 1

HCID 34353313-Methyl-7-(3-methyl-2-buten-1-yl)-8-bromo-xanthine

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6228DimethylformamideSolvent

Procedure

15.37 ml of Hünig base and 9.98 ml of 3,3-dimethylallylbromide are added to 20.00 g of 3-methyl-8-bromo-xanthine in 200 ml of N,N-dimethylformamide. The reaction mixture is stirred for about half an hour at ambient temperature and then diluted with 500 ml of water. The precipitate formed is suction filtered, washed with water and dried.

Workup

  1. customThe precipitate formed
  2. filtrationfiltered
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-93900dfb86194afaabba172dc53d163e
Source dataset
uspto-grants-2009_01
Patent number
US07482337B2

Reaction notes

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