Sodium ethoxide → 5-Bromo-2-(tert-butyl)pyrimidine-4-carboxylic acid

HRID 1455339Notes

Reaction equation

HRID 1455339 reaction equation
[O-]CC.[Na+].[CH3:5][C:6]([C:9]([NH2:11])=[NH:10])([CH3:8])[CH3:7].Cl.[C:13]([OH:21])(=[O:20])/[C:14](=[C:16](\[CH:18]=O)/[Br:17])/Br>C(O)C.Cl>[Br:17][C:16]1[C:14]([C:13]([OH:21])=[O:20])=[N:10][C:9]([C:6]([CH3:8])([CH3:7])[CH3:5])=[N:11][CH:18]=1

Participants

6

Reactant 3

HCID 2723922Sodium ethoxide2×HCID 2781880Propanimidamide, 2,2-dimethyl-, hydrochloride (1:1)HCID 3033972Mucobromic Acid

Product 1

HCID 122589145-Bromo-2-(tert-butyl)pyrimidine-4-carboxylic acidYield 76.6%

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 702EthanolSolvent4×

Conditions

Temperature
50 °C

Procedure

Preparation C1, Step 1: A 22% solution of sodium ethoxide in ethanol (53 mL, 165 mmol) was added dropwise to a magnetically stirred suspension of tert-butylcarbamidine hydrochloride (20.0 g, 146 mmol) in ethanol (100 mL). When the addition was complete, the yellow suspension was warmed to 50° C., the heating mantle was removed, and a solution of mucobromic acid (15.7 g, 61 mmol) in ethanol (50 mL) was added dropwise at a rate which did not allow the temperature to exceed 55° C. When this addition was complete, a 22% solution of sodium ethoxide in ethanol (32 mL, 98 mmol) was added dropwise, then the mixture was allowed to cool to room temperature. The suspension was filtered, the solids were rinsed with ethanol (2×20 mL), and the combined filtrates were concentrated in-vacuo. The residue thus obtained was stirred in 2 N aqueous HCl (30 mL). The resulting solids were collected by filtration, rinsed with ice-cold water (2×20 mL), and air dried to yield 12.1 g of 5-Bromo-2-tert-butyl-pyrimidine-4-carboxylic acid as a beige powder. MS (ES+)=259, 261 (M+H)+.

Workup

  1. additionWhen the addition
  2. customthe heating mantle was removed
  3. customto exceed 55° C
  4. additionWhen this addition
  5. temperatureto cool to room temperature
  6. filtrationThe suspension was filtered
  7. washthe solids were rinsed with ethanol (2×20 mL)
  8. concentrationthe combined filtrates were concentrated in-vacuo
  9. customThe residue thus obtained
  10. filtrationThe resulting solids were collected by filtration
  11. washrinsed with ice-cold water (2×20 mL), and air
  12. customdried

Sources & evidence

ORD record
ord-b04e2c67759340cc8b32e91478188f9d
Source dataset
uspto-grants-2009_01
Patent number
US07482335B2

Reaction notes

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