Oxalyl chloride → 3-Chloro-2,4-difluorobenzoyl chloride

HRID 1455496Notes

Reaction equation

HRID 1455496 reaction equation
[Cl:1][C:2]1[C:3]([F:12])=[C:4]([CH:8]=[CH:9][C:10]=1[F:11])[C:5](O)=[O:6].C(Cl)(=O)C([Cl:16])=O>ClCCl.CN(C=O)C>[Cl:1][C:2]1[C:3]([F:12])=[C:4]([CH:8]=[CH:9][C:10]=1[F:11])[C:5]([Cl:16])=[O:6]

Participants

5

Reactant 2

HCID 65578Oxalyl chlorideHCID 27735323-Chloro-2,4-difluorobenzoic acid

Product 1

HCID 27735383-Chloro-2,4-difluorobenzoyl chloride

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideCatalystHCID 6344DichloromethaneSolvent

Procedure

A quantity of 6.0 g of 3-chloro-2,4-difluorobenzoic acid is suspended in 20 ml of dichloromethane. A quantity of 2.99 ml of oxalyl chloride and 2 drops of DMF are then added. The suspension is stirred at room temperature overnight and the desired product is collected after evaporation of the solvent.

Workup

  1. customthe desired product is collected
  2. customafter evaporation of the solvent

Sources & evidence

ORD record
ord-aaea5ecdabe44c7aa36abdd3fe3621d1
Source dataset
uspto-grants-2009_01
Patent number
US07482454B2

Reaction notes

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