Hydrochloric Acid → 7-[3-Amino-4-methylpiperidinyl]-1-cyclopropyl-1,4-dihydro-8-methoxy-4-oxo-quinoline-3-carboxylic acid hydrochloride salt

HRID 1455498Notes

Reaction equation

HRID 1455498 reaction equation
[NH2:1][CH:2]1[CH:7]([CH3:8])[CH2:6][CH2:5][N:4]([C:9]2[C:18]([O:19][CH3:20])=[C:17]3[C:12]([C:13](=[O:27])[C:14]([C:24]([OH:26])=[O:25])=[CH:15][N:16]3[CH:21]3[CH2:23][CH2:22]3)=[CH:11][CH:10]=2)[CH2:3]1.[ClH:28]>C(O)C>[ClH:28].[NH2:1][CH:2]1[CH:7]([CH3:8])[CH2:6][CH2:5][N:4]([C:9]2[C:18]([O:19][CH3:20])=[C:17]3[C:12]([C:13](=[O:27])[C:14]([C:24]([OH:26])=[O:25])=[CH:15][N:16]3[CH:21]3[CH2:23][CH2:22]3)=[CH:11][CH:10]=2)[CH2:3]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 183331907-[3-Amino-4-methylpiperidinyl]-1-cyclopropyl-1,4-dihydro-8-methoxy-4-oxo-quinoline-3-carboxylic acid

Product 1

HCID 688801277-[3-Amino-4-methylpiperidinyl]-1-cyclopropyl-1,4-dihydro-8-methoxy-4-oxo-quinoline-3-carboxylic acid hydrochloride salt

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A quantity of 0.20 g of 7-[3-amino-4-methylpiperidinyl]-1-cyclopropyl-1,4-dihydro-8-methoxy-4-oxo-quinoline-3-carboxylic acid is suspended in 1.0 mL of ethanol. Its pH is adjusted to 2 with hydrogen chloride to obtain the desired product after the evaporation of solvent.

Sources & evidence

ORD record
ord-7a114be64c2b4976b7588448a0881350
Source dataset
uspto-grants-2009_01
Patent number
US07482454B2

Reaction notes

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