Hydrochloric Acid → 7-[3-Aminopiperidinyl]-1-cyclopropyl-1,4-dihydro-8-methoxy-4-oxo-quinoline-3-carboxylic acid dihydrochloride salt

HRID 1455500Notes

Reaction equation

HRID 1455500 reaction equation
[NH2:1][CH:2]1[CH2:7][CH2:6][CH2:5][N:4]([C:8]2[C:17]([O:18][CH3:19])=[C:16]3[C:11]([C:12](=[O:26])[C:13]([C:23]([OH:25])=[O:24])=[CH:14][N:15]3[CH:20]3[CH2:22][CH2:21]3)=[CH:10][CH:9]=2)[CH2:3]1.[ClH:27]>C(O)C>[ClH:27].[ClH:27].[NH2:1][CH:2]1[CH2:7][CH2:6][CH2:5][N:4]([C:8]2[C:17]([O:18][CH3:19])=[C:16]3[C:11]([C:12](=[O:26])[C:13]([C:23]([OH:25])=[O:24])=[CH:14][N:15]3[CH:20]3[CH2:22][CH2:21]3)=[CH:10][CH:9]=2)[CH2:3]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 9863559Nemonoxacin Impurity 77

Product 1

HCID 688826357-[3-Aminopiperidinyl]-1-cyclopropyl-1,4-dihydro-8-methoxy-4-oxo-quinoline-3-carboxylic acid dihydrochloride salt

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A quantity of 0.19 g of 7-[3-aminopiperidinyl]-1-cyclopropyl-1,4-dihydro-8-methoxy-4-oxo-quinoline-3-carboxylic acid is suspended in 1.0 mL of ethanol. The pH of the solution is adjusted to 2 with the addition of hydrogen chloride. The desired product is obtained by evaporation of the solvent.

Sources & evidence

ORD record
ord-77992d916ad5451fbbf8dbabbf7dbf29
Source dataset
uspto-grants-2009_01
Patent number
US07482454B2

Reaction notes

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