Hydrochloric Acid → HCID 86597094, compound

HRID 1455544Notes

Reaction equation

HRID 1455544 reaction equation
CCN(C(C)C)C(C)C.F[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[N+:17]([O-:19])=[O:18].[NH:20]1[CH2:25][CH2:24][CH:23]([C:26]([NH:28][S:29]([C:32]2[CH:37]=[C:36]([C:38]([F:41])([F:40])[F:39])[CH:35]=[C:34]([C:42]([F:45])([F:44])[F:43])[CH:33]=2)(=[O:31])=[O:30])=[O:27])[CH2:22][CH2:21]1.Cl>CS(C)=O>[N+:17]([C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=1[N:20]1[CH2:25][CH2:24][CH:23]([C:26]([NH:28][S:29]([C:32]2[CH:33]=[C:34]([C:42]([F:43])([F:44])[F:45])[CH:35]=[C:36]([C:38]([F:41])([F:39])[F:40])[CH:37]=2)(=[O:30])=[O:31])=[O:27])[CH2:22][CH2:21]1)([O-:19])=[O:18]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 738951-Fluoro-2-nitrobenzeneHCID 81531DiisopropylethylamineHCID 86597095HCID 86597095, compound

Product 1

HCID 86597094HCID 86597094, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

0.13 g of DIEA and 0.07 g of 1-fluoro-2-nitrobenzene are added to a solution of 0.22 g N-(piperidine-4-carbonyl)-3,5-bis-trifluoromethyl-benzenesulfonamide in the form of a hydrochloride in 4 ml of DMSO. The mixture obtained is stirred for ca. 18 h at 80°, solvent is evaporated and the evaporation residue is subjected to flash chromatography on silica gel (eluent: EtAc). N-[1-(2-Nitro-phenyl)-piperidine-4-carbonyl]-3,5-bis-trifluoromethyl-benzenesulfonamide is obtained.

Workup

  1. customThe mixture obtained
  2. customsolvent is evaporated

Sources & evidence

ORD record
ord-344478808b274814907e253c9fe3e8b9
Source dataset
uspto-grants-2009_01
Patent number
US07482462B2

Reaction notes

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