HCID 53750208, compound → HCID 57429713, compound

HRID 1455563Notes

Reaction equation

HRID 1455563 reaction equation
[CH2:1]([O:3][C:4]([C:6]1([C:11]2[CH:16]=[CH:15][N:14]=[CH:13][CH:12]=2)[CH2:10][CH2:9][CH2:8][CH2:7]1)=[O:5])[CH3:2]>CO.Cl.O=[Pt]=O>[CH2:1]([O:3][C:4]([C:6]1([CH:11]2[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]2)[CH2:10][CH2:9][CH2:8][CH2:7]1)=[O:5])[CH3:2]

Participants

5

Reactant 1

HCID 53750208HCID 53750208, compound

Product 1

HCID 57429713HCID 57429713, compound

Reagents, catalysts & solvents 3

HCID 345198Adams' catalystCatalystHCID 313Hydrochloric AcidSolventHCID 887MethanolSolvent

Procedure

1.75 g of 1-pyridin-4-yl-cyclopentanecarboxylic acid ethyl ester are dissolved in a mixture of 100 ml of MeOH and aqueous HCl (32%) and the mixture obtained is hydrogenated in the presence of 175 mg of PtO2 as a catalyst under pressure for 5 hours. From the mixture obtained the catalyst is removed by filtration and solvent is evaporated. 1-Piperidin-4-yl-cyclopentanecarboxylic acid ethyl ester in the form of a hydrochloride salt is obtained. 13C-NMR (CD3OD): 176.73, 61.33, 57.71, 45.08, 45.00, 42.14, 33.80, 25.49, 25.43, 25.36, 14.58.

Workup

  1. customthe mixture obtained
  2. customFrom the mixture obtained the catalyst
  3. customis removed by filtration and solvent
  4. customis evaporated

Sources & evidence

ORD record
ord-b09a8b50b452413d91ec83caa7169a6e
Source dataset
uspto-grants-2009_01
Patent number
US07482462B2

Reaction notes

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