Benzyl Bromide → HCID 57535395, compound

HRID 1455640Notes

Reaction equation

HRID 1455640 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([C:9]2[O:13][N:12]=[C:11]([CH3:14])[N:10]=2)[C:5]([OH:8])=[N:6][CH:7]=1.[CH2:15](Br)[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>C1C=CC=CC=1.C(=O)([O-])[O-].[Ag+2]>[CH2:15]([O:8][C:5]1[C:4]([C:9]2[O:13][N:12]=[C:11]([CH3:14])[N:10]=2)=[CH:3][C:2]([Br:1])=[CH:7][N:6]=1)[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

Participants

5

Reactant 2

HCID 7498Benzyl BromideHCID 178434719HCID 178434719, compound

Product 1

HCID 57535395HCID 57535395, compound

Reagents, catalysts & solvents 2

HCID 178418647HCID 178418647, compoundCatalystHCID 241BenzeneSolvent

Conditions

Temperature
20 °C

Procedure

A solution 5-bromo-3-(3-methyl-1,2,4-oxadiazol-5-yl)pyridin-2-ol (1 eq) in benzene (0.05M) was added silver carbonate (1 eq) and benzyl bromide (1.2 eq). The reaction mixture was stirred 6 h at 20° C. and then concentrated. The residue was purified by flash chromatography (Hexane:EtOAc, 90:10) to afforded the title compound.

Workup

  1. concentrationconcentrated
  2. customThe residue was purified by flash chromatography (Hexane:EtOAc, 90:10)

Sources & evidence

ORD record
ord-e0e9635af48947528f6c3d1adbf315fb
Source dataset
uspto-grants-2009_01
Patent number
US07482456B2

Reaction notes

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