Iodoethane → HCID 18440694, compound

HRID 1455683Notes

Reaction equation

HRID 1455683 reaction equation
[Cl:1][C:2]1[S:6][C:5]([C:7]([NH:9][C:10]2[CH:18]=[CH:17][CH:16]=[C:15]3[C:11]=2[C:12](=[O:28])[N:13]([CH2:20][CH2:21][CH:22]2[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]2)[C:14]3=[O:19])=[O:8])=[CH:4][CH:3]=1.[CH:29](N(CC)C(C)C)(C)[CH3:30].ICC>O1CCOCC1>[Cl:1][C:2]1[S:6][C:5]([C:7]([NH:9][C:10]2[CH:18]=[CH:17][CH:16]=[C:15]3[C:11]=2[C:12](=[O:28])[N:13]([CH2:20][CH2:21][CH:22]2[CH2:27][CH2:26][N:25]([CH2:29][CH3:30])[CH2:24][CH2:23]2)[C:14]3=[O:19])=[O:8])=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 6340IodoethaneHCID 81531DiisopropylethylamineHCID 18440685HCID 18440685, compound

Product 1

HCID 18440694HCID 18440694, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

50.1 mg (0.12 mmol) of 5-chloro-N-{1,3-dioxo-2-[2-(4-piperidinyl)ethyl]-2,3-dihydro-1H-isoindol-4-yl}-2-thiophenecarboxamide are dissolved in 1 ml of 1,4-dioxane, and 25 μl (0.144 mmol) of N,N-diisopropylethylamine and 10 μl (0.12 mmol) of iodoethane are added. The mixture is stirred at room temperature overnight and, after concentration, chromatographed on silica gel (dichloromethane/methanol 97:3).

Workup

  1. concentrationafter concentration
  2. customchromatographed on silica gel (dichloromethane/methanol 97:3)

Sources & evidence

ORD record
ord-44f4faa16d2c4e158c3472d1a4598bec
Source dataset
uspto-grants-2009_01
Patent number
US07482472B2

Reaction notes

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