Benzylamine → HCID 3853004, compound

HRID 1455730Notes

Reaction equation

HRID 1455730 reaction equation
[CH2:1]([NH2:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:9]([C:11]1[CH:12]=[C:13]([S:17](Cl)(=[O:19])=[O:18])[CH:14]=[CH:15][CH:16]=1)#[N:10].C(N(CC)CC)C>O1CCCC1.O>[CH2:1]([NH:8][S:17]([C:13]1[CH:14]=[CH:15][CH:16]=[C:11]([C:9]#[N:10])[CH:12]=1)(=[O:19])=[O:18])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

6

Reactant 3

HCID 7504BenzylamineHCID 8471TriethylamineHCID 28013603-Cyanobenzene-1-sulfonyl chloride

Product 1

HCID 3853004HCID 3853004, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

Benzylamine (1.17 g, 10 mmol) was added to a solution of 3-cyanobenzene sulphonyl chloride (2 g, 10 mmol) and triethylamine (3.45 ml, 25 mmol) in tetrahydrofuran (30 ml) and the mixture stirred at room temperature for 18 hours. The mixture was diluted with water (30 ml), and extracted with ethyl acetate (50 ml). The organic extract was dried over sodium sulphate and evaporated under reduced pressure to give the title compound as a solid, 2.53 g.

Workup

  1. extractionextracted with ethyl acetate (50 ml)
  2. extractionThe organic extract
  3. dry with materialwas dried over sodium sulphate
  4. customevaporated under reduced pressure

Sources & evidence

ORD record
ord-f04c1305529a48d7990c705ba8ad5acb
Source dataset
uspto-grants-2009_01
Patent number
US07482487B2

Reaction notes

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