Hydrochloric Acid → HCID 22105647, compound

HRID 1455985Notes

Reaction equation

HRID 1455985 reaction equation
C1O[CH:4]([C:5]2[CH:10]=[C:9]([S:11]([CH3:14])(=[O:13])=[O:12])[CH:8]=[CH:7][C:6]=2[O:15][CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[O:3]C1.Cl>C1COCC1.CO>[CH2:16]([O:15][C:6]1[CH:7]=[CH:8][C:9]([S:11]([CH3:14])(=[O:13])=[O:12])=[CH:10][C:5]=1[CH:4]=[O:3])[C:17]1[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 22105597HCID 22105597, compound

Product 1

HCID 22105647HCID 22105647, compoundYield 96.6%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

A solution of 2-benzyloxy-5-methylsulphonylbenzaldehyde ethylene acetal (28.6 g) in THF (100 ml) and MeOH (100 ml) containing 2N HCl (50 ml) was stirred for 4 hours. The reaction mixture was concentrated to half its volume and water (100 ml) was added. The solid product was filtered and dried to give 2-benzyloxy-5-methylsulphonylbenzaldehyde yield 24 g m.p. 129° C.

Workup

  1. concentrationThe reaction mixture was concentrated to half its volume and water (100 ml)
  2. additionwas added
  3. filtrationThe solid product was filtered
  4. customdried

Sources & evidence

ORD record
ord-4e8fe4517e0b4f2fbaee868711b68a41
Source dataset
uspto-grants-1998_12
Patent number
US05843942

Reaction notes

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