反应详情

A mixture of 1-fluoro-4-nitrobenzene (20 g), potassium carbonate (23.5 g) and 1H-tetrazole (12 g) in dimethylformamide (60 ml) was heated to 100° under nitrogen for 24 h. On cooling, the solvent was evaporated and the residue taken up in water, extracted with dichloromethane (4×100 ml), dried (Na2SO4) and evaporated to give an orange solid. This was purified by FCC (cyclohexane/ethyl acetate (3:1)) to give the title compound as a solid (6.5 g).

1. temperaturewas heated to 100° under nitrogen for 24 h
2. temperatureOn cooling
3. customthe solvent was evaporated
4. extractionextracted with dichloromethane (4×100 ml)
5. dry with materialdried (Na2SO4)
6. customevaporated
7. customto give an orange solid
8. customThis was purified by FCC (cyclohexane/ethyl acetate (3:1))