4-Methylthiazole → HCID 22915161, compound

HRID 1456337Notes

Reaction equation

HRID 1456337 reaction equation
[CH3:1][C:2]1[N:3]=[CH:4][S:5][CH:6]=1.[CH3:7][C:8]1[N:9]=[C:10]([C:13](=[O:18])[C:14]([F:17])([F:16])[F:15])[S:11][CH:12]=1>O1CCCC1>[CH3:1][C:2]1[N:3]=[C:4]([C:13]([C:10]2[S:11][CH:12]=[C:8]([CH3:7])[N:9]=2)([OH:18])[C:14]([F:17])([F:16])[F:15])[S:5][CH:6]=1

Participants

4

Reactant 2

HCID 127484-MethylthiazoleHCID 221066902,2,2-Trifluoro-1-(4-methyl-1,3-thiazol-2-yl)ethan-1-one

Product 1

HCID 22915161HCID 22915161, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

From 4-methylthiazole and 4-methyl-2-trifluoroacetylthiazole and using anhydrous tetrahydrofuran as solvent. M.p. 140°-142.5° C. 13C Nmr (CDCl3) 17.0, 77.5 (q, J 31 Hz), 117.1, 122.6 (q, J 284 Hz), 152.5 and 163.9 ppm.

Sources & evidence

ORD record
ord-82244b98640140c18081098d61ac44b4
Source dataset
uspto-grants-1998_12
Patent number
US05843971

Reaction notes

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