Hydrochloric Acid → HCID 67584157, compound

HRID 1456558Notes

Reaction equation

HRID 1456558 reaction equation
[F:1][C:2]1[CH:17]=[CH:16][C:5]([O:6][CH2:7][CH2:8][C@@H:9]2[CH2:13][C@@H:12]([OH:14])[CH2:11][N:10]2[CH3:15])=[C:4]([CH2:18][CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[CH:3]=1.[ClH:26]>C(OCC)(=O)C>[ClH:26].[F:1][C:2]1[CH:17]=[CH:16][C:5]([O:6][CH2:7][CH2:8][C@@H:9]2[CH2:13][C@@H:12]([OH:14])[CH2:11][N:10]2[CH3:15])=[C:4]([CH2:18][CH2:19][C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=2)[CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 54563963HCID 54563963, compound

Product 1

HCID 67584157HCID 67584157, compoundYield 86%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

540 mg of (2R,4R)-2-{2-[4-fluoro-2-(2-phenylethyl)phenoxy]ethyl}-4-hydroxy-1-methylpyrrolidine [prepared as described in step (b) above] were dissolved in 5 ml of ethyl acetate, and then 0.60 ml of a 4N solution of hydrogen chloride in ethyl acetate were added to the resulting solution. The crystals which precipitated were collected by filtration, and dried in vacuo, to give 515 mg (yield 86%) of the title compound as colorless crystals, melting at 121°-122° C.

Workup

  1. customThe crystals which precipitated
  2. filtrationwere collected by filtration
  3. customdried in vacuo

Sources & evidence

ORD record
ord-2cc2055669be4db6b1fe45d5dc8146c2
Source dataset
uspto-grants-1998_12
Patent number
US05843983

Reaction notes

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