Hydrochloric Acid → HCID 67694283, compound

HRID 1456591Notes

Reaction equation

HRID 1456591 reaction equation
[F:1][C:2]1[CH:30]=[CH:29][C:5]([O:6][CH2:7][CH2:8][C@@H:9]2[CH2:13][C@@H:12]([O:14][C:15](=[O:27])[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26])[CH2:11][N:10]2[CH3:28])=[C:4]([CH2:31][CH2:32][C:33]2[CH:38]=[CH:37][CH:36]=[C:35]([O:39][CH3:40])[CH:34]=2)[CH:3]=1.[ClH:41]>O1CCOCC1>[ClH:41].[F:1][C:2]1[CH:30]=[CH:29][C:5]([O:6][CH2:7][CH2:8][C@@H:9]2[CH2:13][C@@H:12]([O:14][C:15](=[O:27])[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26])[CH2:11][N:10]2[CH3:28])=[C:4]([CH2:31][CH2:32][C:33]2[CH:38]=[CH:37][CH:36]=[C:35]([O:39][CH3:40])[CH:34]=2)[CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67694230HCID 67694230, compound

Product 1

HCID 67694283HCID 67694283, compoundYield 97%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

1.34 g of (2R,4R)-2-[2-{4-fluoro-2-[2-(3-methoxyphenyl)ethyl]phenoxy}-ethyl]-4-lauroyloxy-1-methylpyrrolidine [prepared as described in step (a) above] were dissolved in 15 ml of dioxane, and 0.90 ml of a 4N solution of hydrogen chloride in dioxane was added to the resulting solution. The solution was then concentrated by evaporation under reduced pressure. The resulting residue was purified by decantation three times with hexane, and the resulting oily substance was dried in vacuo, to give 1.39 g (yield 97%) of the title compound as a colorless oily substance.

Workup

  1. concentrationThe solution was then concentrated by evaporation under reduced pressure
  2. customThe resulting residue was purified by decantation three times with hexane
  3. customthe resulting oily substance was dried in vacuo

Sources & evidence

ORD record
ord-6527bd38263442808b98c0461dba7f42
Source dataset
uspto-grants-1998_12
Patent number
US05843983

Reaction notes

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