Hydrochloric Acid → HCID 22106952, compound

HRID 1456596Notes

Reaction equation

HRID 1456596 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([O:8]COC)=[C:4]([CH2:12][CH2:13][C:14]2[CH:19]=[CH:18][C:17]([F:20])=[CH:16][CH:15]=2)[CH:3]=1.Cl>C(OCC)(=O)C>[F:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[C:4]([CH2:12][CH2:13][C:14]2[CH:15]=[CH:16][C:17]([F:20])=[CH:18][CH:19]=2)[CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 85746095HCID 85746095, compound

Product 1

HCID 22106952HCID 22106952, compoundYield 99%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

1785 mg of methoxymethyl {4-fluoro-2-[2-(4-fluorophenyl)ethyl]phenyl} ether [prepared as described in step (a) above] were dissolved in 8 ml of ethyl acetate, and then 8 ml of a 4N solution of hydrogen chloride in ethyl acetate were added to the resulting solution, whilst ice-cooling. The resulting mixture was allowed to stand at room temperature for 2 hours, after which it was concentrated by evaporation under reduced pressure, and purified by silica gel column chromatography, using a 4:1 by volume mixture of hexane and ethyl acetate as the eluent, to give 1483 mg (yield 99%) of the title compound as an oily substance.

Workup

  1. temperaturecooling
  2. concentrationafter which it was concentrated by evaporation under reduced pressure
  3. custompurified by silica gel column chromatography
  4. additionby volume mixture of hexane and ethyl acetate as the eluent

Sources & evidence

ORD record
ord-4b1169394c324a8aa3e59dbc65ad61cb
Source dataset
uspto-grants-1998_12
Patent number
US05843983

Reaction notes

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