Trifluoroacetic acid → ((2(S)-Benzoylamino-3-methylbutyryl)indan-2-ylamino)acetic Acid

HRID 1456662Notes

Reaction equation

HRID 1456662 reaction equation
C([O:5][C:6](=[O:33])[CH2:7][N:8]([C:18](=[O:32])[C@@H:19]([NH:23][C:24](=[O:31])[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)[CH:20]([CH3:22])[CH3:21])[CH:9]1[CH2:17][C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[CH2:10]1)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[C:24]([NH:23][C@@H:19]([CH:20]([CH3:22])[CH3:21])[C:18]([N:8]([CH2:7][C:6]([OH:33])=[O:5])[CH:9]1[CH2:10][C:11]2[C:16](=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH2:17]1)=[O:32])(=[O:31])[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 54431002((2(S)-Benzoylamino-3-methylbutyryl)indan-2-ylamino)acetic Acid t-Butyl Ester

Product 1

HCID 54183224((2(S)-Benzoylamino-3-methylbutyryl)indan-2-ylamino)acetic Acid

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of compound 723 (240 mg, 0.53 mmol) in CH2Cl2 (4.0 mL) was added TFA (2.0 mL) and the reaction stirred at rt for 1 hr. The reaction was concentrated in vacuo and the residue co-concentrated with toluene. The material was used directly in the next reaction without further purification. ##STR103##

Workup

  1. concentrationThe reaction was concentrated in vacuo
  2. customThe material was used directly in the next reaction without further purification

Sources & evidence

ORD record
ord-d05609d843c44467bfbbb62272369a9e
Source dataset
uspto-grants-1998_12
Patent number
US05843904

Reaction notes

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