1-Methyl-4-piperidone → 7-Fluoro-3-(1,2,3,6-tetrahydro-1-methyl-4-pyridinyl)-1H-indole

HRID 1456971Notes

Reaction equation

HRID 1456971 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[NH:9][CH:8]=[CH:7]2.[CH3:11][N:12]1[CH2:17][CH2:16][C:15](=O)[CH2:14][CH2:13]1>>[F:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[NH:9][CH:8]=[C:7]2[C:15]1[CH2:16][CH2:17][N:12]([CH3:11])[CH2:13][CH:14]=1

Participants

3

Reactant 2

HCID 740491-Methyl-4-piperidoneHCID 27745047-Fluoro-1H-indole

Product 1

HCID 187971587-Fluoro-3-(1,2,3,6-tetrahydro-1-methyl-4-pyridinyl)-1H-indoleYield 75.1%

Procedure

Beginning with 0.50 gm (3.70 mMol) 7-fluoro-1H-indole and 0.91 mL (7.4 mMol) 1-methyl-4-piperidone, 0.64 gm (75%) of the title compound were recovered as a white solid.

Sources & evidence

ORD record
ord-857368048ea142e4994883d1f6094dc7
Source dataset
uspto-grants-1998_12
Patent number
US05846982

Reaction notes

Loading…